Structure of PDB 3c3n Chain A

Receptor sequence
>3c3nA (length=311) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
CLKLNLLDHVFANPFMNAAGVLCSTEEDLRCMTASSSGALVSKSCTSAPR
DGNPEPRYMAVPLGSINSMGLPNLGFDFYLKYASDLHDYSKKPLFLSISG
LSVEENVAMVRRLAPVAQEKGVLLELNLSCPNVPGKPQVAYDFEAMRTYL
QQVSLAYGLPFGVKMPPYFDIAHFDTAAAVLNEFPLVKFVTCVNSVGNGL
VIDAESESVVIKPKQGFGGLGGKYILPTALANVNAFYRRCPDKLVFGCGG
VYSGEDAFLHILAGASMVQVGTALQEEGPGIFTRLEDELLEIMARKGYRT
LEEFRGRVKTI
3D structure
PDB3c3n Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K45 N69 L73 C132 N134 V135 K166 V195
Catalytic site (residue number reindexed from 1) K43 N67 L71 C130 N132 V133 K164 V193
Enzyme Commision number 1.3.98.1: dihydroorotate oxidase (fumarate).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A A20 A21 G22 K45 S46 Y60 N69 M71 N129 K166 N196 S197 G223 G224 I227 C250 G251 G252 G273 T274 A18 A19 G20 K43 S44 Y58 N67 M69 N127 K164 N194 S195 G221 G222 I225 C248 G249 G250 G271 T272
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:1990663 dihydroorotate dehydrogenase (fumarate) activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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External links
PDB RCSB:3c3n, PDBe:3c3n, PDBj:3c3n
PDBsum3c3n
PubMed18302934
UniProtQ4D3W2|PYRD_TRYCC Dihydroorotate dehydrogenase (fumarate) (Gene Name=pyr4)

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