Structure of PDB 3c2f Chain A

Receptor sequence
>3c2fA (length=267) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PVYEHLLPVNGAWRQDVTNWLSEDVPSFDFGGYVVGSDLKEANLYCKQDG
MLCGVPFAQEVFNQCELQVEWLFKEGSFLEPSKNDSGKIVVAKITGPAKN
ILLAERTALNILSRSSGIATASHKIISLARSTGYKGTIAGTRKTTPGLRR
LEKYSMLVGGCDTHRYDLSSMVMLKDNHIWATGSITNAVKNARAVCGFAV
KIEVECLSEDEATEAIEAGADVIMLDNHFLLECSGGLNLLCDDIDIYSTS
SIHQGTPVIDFSLKLAH
3D structure
PDB3c2f Comprehensive X-ray Structural Studies of the Quinolinate Phosphoribosyl Transferase (BNA6) from Saccharomyces cerevisiae.
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R107 K144 K176 E206 D227
Catalytic site (residue number reindexed from 1) R106 K143 K175 E205 D226
Enzyme Commision number 2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRP A K144 S256 G257 T277 S278 K143 S234 G235 T249 S250 MOAD: Kd=10.1mM
PDBbind-CN: -logKd/Ki=2.00,Kd=10.1mM
Gene Ontology
Molecular Function
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0034213 quinolinate catabolic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3c2f, PDBe:3c2f, PDBj:3c2f
PDBsum3c2f
PubMed18321072
UniProtP43619|NADC_YEAST Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Gene Name=BNA6)

[Back to BioLiP]