Structure of PDB 3c1m Chain A

Receptor sequence
>3c1mA (length=465) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
TTVMKFGGTSVGSGERIRHVAKIVTKRKKEDDDVVVVVSAMSEVTNALVE
ISQQALDVRDIAKVGDFIKFIREKHYKAIEEAIKSEEIKEEVKKIIDSRI
EELEKVLIGVAYLGELTPKSRDYILSFGERLSSPILSGAIRDLGEKSIAL
EGGEAGIITDNNFGSARVKRLEVKERLLPLLKEGIIPVVTGFIGTTEEGY
ITTLGRGGSDYSAALIGYGLDADIIEIWTDVSGVYTTDPRLVPTARRIPK
LSYIEAMELAYFGAKVLHPRTIEPAMEKGIPILVKNTFEPESEGTLITND
MEMSDSIVKAISTIKNVALINIFGAGMVGVSGTAARIFKALGEEEVNVIL
ISQGSSETNISLVVSEEDVDKALKALKREFGDSFLNNNLIRDVSVDKDVC
VISVVGAGMRGAKGIAGKIFTAVSESGANIKMIAQGSSEVNISFVIDEKD
LLNCVRKLHEKFIEK
3D structure
PDB3c1m The Structural Basis for Allosteric Inhibition of a Threonine-sensitive Aspartokinase.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.2.4: aspartate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP A T46 E130 F193 R207 G208 S210 T45 E129 F192 R206 G207 S209
BS02 ANP A K6 G8 G9 S40 T230 D231 V232 V235 Y236 D239 R241 K266 V267 K5 G7 G8 S39 T229 D230 V231 V234 Y235 D238 R240 K265 V266
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004072 aspartate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009088 threonine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0009090 homoserine biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c1m, PDBe:3c1m, PDBj:3c1m
PDBsum3c1m
PubMed18334478
UniProtQ57991|AK_METJA Probable aspartokinase (Gene Name=MJ0571)

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