Structure of PDB 3c0z Chain A

Receptor sequence
>3c0zA (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
TLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQC
ECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQVMLP
CGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPP
GHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQT
FYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDP
PMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA
KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPL
SEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQR
3D structure
PDB3c0z Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D707 H709 D801 D190 H192 D284
BS02 ZN A C533 C535 H541 C618 C19 C21 H27 C101
BS03 SHH A H669 H670 F679 D707 H709 F738 H152 H153 F162 D190 H192 F221 MOAD: ic50=113uM
PDBbind-CN: -logKd/Ki=3.95,IC50=113uM
BindingDB: IC50=>10000nM,Ki=129nM,Kd=36000nM
External links
PDB RCSB:3c0z, PDBe:3c0z, PDBj:3c0z
PDBsum3c0z
PubMed18285338
UniProtQ8WUI4|HDAC7_HUMAN Histone deacetylase 7 (Gene Name=HDAC7)

[Back to BioLiP]