Structure of PDB 3c0i Chain A

Receptor sequence
>3c0iA (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
VLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS
TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVK
RADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENS
APVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGC
GVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRR
MLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRK
3D structure
PDB3c0i CASK Functions as a Mg2+-independent neurexin kinase
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 H145 C146 G162 T182
Catalytic site (residue number reindexed from 1) D136 K138 H140 C141 G157 T177
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3AM A V26 A39 K41 F91 M94 L148 G162 V21 A34 K36 F86 M89 L143 G157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3c0i, PDBe:3c0i, PDBj:3c0i
PDBsum3c0i
PubMed18423203
UniProtO14936|CSKP_HUMAN Peripheral plasma membrane protein CASK (Gene Name=CASK)

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