Structure of PDB 3bz8 Chain A

Receptor sequence
>3bz8A (length=703) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGE
IVSETSDSFTFKTVDQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPAV
FHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEVA
PHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAGR
VLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAGFISGASIQ
SYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYLNQ
SGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNIKF
EKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHL
NVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISGFE
IFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFGLD
SQATIDLIDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYE
EPRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVT
KLFNDPNIASRAKKGANFITVAAQYKEQLASLMATLETTNPHFVRCIIPN
NKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYFVQYRFGITKI
FFR
3D structure
PDB3bz8 The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S181 G182 T186 N233 S236 S237 G457 E459
Catalytic site (residue number reindexed from 1) S179 G180 T184 N224 S227 S228 G448 E450
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T186 S237 T184 S228
BS02 ADP A N127 P128 F129 K130 G182 G184 K185 T186 E187 N233 N125 P126 F127 K128 G180 G182 K183 T184 E185 N224
BS03 BL6 A F239 G240 Y261 L262 S456 C470 T474 Y634 Q637 L638 F230 G231 Y252 L253 S447 C461 T465 Y625 Q628 L629
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:3bz8, PDBe:3bz8, PDBj:3bz8
PDBsum3bz8
PubMed18528569
UniProtP08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA)

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