Structure of PDB 3bz3 Chain A

Receptor sequence
>3bz3A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
DYEIQRERIELGRCIGEGQFGDVHQGIYMSPLAVAIKTCKNCTSDSVREK
FLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYS
LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGL
SRYLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNND
VIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTIL
EEEKAQQEE
3D structure
PDB3bz3 Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564
Catalytic site (residue number reindexed from 1) D129 A131 R133 N134 D147
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YAM A R426 I428 V436 A452 E500 L501 C502 G505 L553 D564 L567 S568 R13 I15 V23 A35 E83 L84 C85 G88 L136 D147 L150 S151 MOAD: ic50=1.5nM
PDBbind-CN: -logKd/Ki=8.82,IC50=1.5nM
BindingDB: IC50=1.5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3bz3, PDBe:3bz3, PDBj:3bz3
PDBsum3bz3
PubMed18339875
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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