Structure of PDB 3bxo Chain A

Receptor sequence
>3bxoA (length=236) Species: 54571 (Streptomyces venezuelae) [Search protein sequence]
YEVDHADVYDLFYLGRGKDYAAEASDIADLVRSRTPEASSLLDVACGTGT
HLEHFTKEFGDTAGLELSEDMLTHARKRLPDATLHQGDMRDFRLGRKFSA
VVSMFSSVGYLKTTEELGAAVASFAEHLEPGGVVVVEPWWFPETFADGWV
SADVVRRDGRTVARVSHSVREGNATRMEVHFTVADPGKGVRHFSDVHLIT
LFHQAEYEAAFTAAGLRVEYLEGGPSGRGLFVGVPA
3D structure
PDB3bxo Three-Dimensional Structure of DesVI from Streptomyces venezuelae: A Sugar N,N-Dimethyltransferase Required for dTDP-Desosamine Biosynthesis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.234: dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A Y21 A46 H52 E67 L68 D89 M90 F106 S108 Y20 A45 H51 E66 L67 D88 M89 F105 S107
BS02 UPP A Y14 R17 F106 W140 W141 T145 F146 A147 W150 S152 R165 S167 S169 M178 R229 Y13 R16 F105 W139 W140 T144 F145 A146 W149 S151 R164 S166 S168 M177 R228
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0009058 biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3bxo, PDBe:3bxo, PDBj:3bxo
PDBsum3bxo
PubMed18327916
UniProtQ9ZGH6|DESVI_STRVZ dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (Gene Name=desVI)

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