Structure of PDB 3bv0 Chain A

Receptor sequence
>3bv0A (length=410) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
GLTPEQIIAVDGAHLWHPSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWW
TAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGL
DTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFLAM
SICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELA
AVVVEPVVQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGA
LFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAHTISAGPTFMANP
LACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGA
IGVIECDRPVDLAVATPAALDRGVWLRPFRNLVYAMPPYICTPAEITQIT
SAMVEVARLV
3D structure
PDB3bv0 Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
ChainA
Resolution2.21 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y157 E220 D254 A257 K283 Y407
Catalytic site (residue number reindexed from 1) Y142 E205 D239 A242 K268 Y384
Enzyme Commision number 2.6.1.62: adenosylmethionine--8-amino-7-oxononanoate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G124 S125 Y157 H158 G159 E220 D254 I256 K283 G109 S110 Y142 H143 G144 E205 D239 I241 K268
BS02 PLP A P317 T318 P294 T295
Gene Ontology
Molecular Function
GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009102 biotin biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3bv0, PDBe:3bv0, PDBj:3bv0
PDBsum3bv0
PubMed20565114
UniProtP9WQ81|BIOA_MYCTU Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (Gene Name=bioA)

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