Structure of PDB 3bua Chain A

Receptor sequence
>3buaA (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
GEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGK
EHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEF
TLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRN
DLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKA
LK
3D structure
PDB3bua A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A R80 Q84 L87 V88 E94 S98 L101 R102 M104 Q105 S108 R109 C118 S119 F120 M122 R37 Q41 L44 V45 E51 S55 L58 R59 M61 Q62 S65 R66 C75 S76 F77 M79
BS02 peptide A M122 E123 M79 E80
Gene Ontology
Molecular Function
GO:0042162 telomeric DNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0031848 protection from non-homologous end joining at telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:3bua, PDBe:3bua, PDBj:3bua
PDBsum3bua
PubMed18202258
UniProtQ15554|TERF2_HUMAN Telomeric repeat-binding factor 2 (Gene Name=TERF2)

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