Structure of PDB 3bu8 Chain A

Receptor sequence
>3bu8A (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
GEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGK
EHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEF
TLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRN
DLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKA
LKSE
3D structure
PDB3bu8 A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R80 Q84 L87 R102 Q105 S108 R109 L116 D117 S119 F120 D121 A124 E125 L126 N168 E170 K173 R37 Q41 L44 R59 Q62 S65 R66 L73 D74 S76 F77 D78 A81 E82 L83 N125 E127 K130
Gene Ontology
Molecular Function
GO:0042162 telomeric DNA binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000723 telomere maintenance
GO:0031848 protection from non-homologous end joining at telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3bu8, PDBe:3bu8, PDBj:3bu8
PDBsum3bu8
PubMed18202258
UniProtQ15554|TERF2_HUMAN Telomeric repeat-binding factor 2 (Gene Name=TERF2)

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