Structure of PDB 3bu6 Chain A

Receptor sequence
>3bu6A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESA
SLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS
YLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAAR
NCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVF
TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPE
RVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK
3D structure
PDB3bu6 Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1132 A1134 R1136 N1137 D1150 E1159 L1171
Catalytic site (residue number reindexed from 1) D146 A148 R150 N151 D164 E173 L185
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M1079 D1083 K1085 S1086 D1132 R1136 N1137 K1165 G1166 G1167 K1168 G1169 L1170 L1171 P1172 W1175 S1180 L1181 K1182 G1184 Q1208 N1215 M93 D97 K99 S100 D146 R150 N151 K179 G180 G181 K182 G183 L184 L185 P186 W189 S194 L195 K196 G198 Q222 N229
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3bu6, PDBe:3bu6, PDBj:3bu6
PDBsum3bu6
PubMed18278056
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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