Structure of PDB 3bu0 Chain A

Receptor sequence

>3bu0A (length=203) Species: 9606 (Homo sapiens)

SWRHIRAEGLDSSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKW
HSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNF
VLINRYKDGSDHIGEHRDDCRELAPGSPIASVSFGASRDFVFRHKDSRGK
SPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRK
ILL

3D structure

• PDB: 3bu0 Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 1.14.11.33: DNA oxidative demethylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	V101 F102 H106 P109 R110 Y122 F124 S125 H167 I168 G169 H171 C175 Y235	V46 F47 H51 P54 R55 Y67 F69 S70 H112 I113 G114 H116 C120 Y180
BS02	dna	A	F102 G103 K104 R198 G204 K205 R241 K242 K243	F47 G48 K49 R143 G149 K150 R186 K187 K188
BS03	AKG	A	L157 N159 Y161 I168 H171 H236 R248 N250	L102 N104 Y106 I113 H116 H181 R193 N195
BS04	MN	A	H171 D173 H236	H116 D118 H181

Gene Ontology

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:3bu0, PDBe:3bu0, PDBj:3bu0
• PDBsum: 3bu0
• PubMed: 18432238
• UniProt: Q6NS38|ALKB2_HUMAN DNA oxidative demethylase ALKBH2 (Gene Name=ALKBH2)