Structure of PDB 3brh Chain A

Receptor sequence
>3brhA (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
QREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKP
KNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIAT
QGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLE
FGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPAHDVPSSI
DPILELIWDVRCYQEDDSVPICIHSSAGCGRTGVICAIDYTWMLLKDGII
PENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIR
3D structure
PDB3brh Lyp/PTPN22 Phosphatase Domain: Substrate Recognition and Specificity for Src family kinases
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A195 S227 R233 T234 Q274
Catalytic site (residue number reindexed from 1) A193 S225 R231 T232 Q272
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K32 Y60 K61 D62 A195 H196 A229 S271 Q274 K30 Y58 K59 D60 A193 H194 A227 S269 Q272
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3brh, PDBe:3brh, PDBj:3brh
PDBsum3brh
PubMed
UniProtQ9Y2R2|PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (Gene Name=PTPN22)

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