Structure of PDB 3brb Chain A

Receptor sequence
>3brbA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
NKLEDVVIDRNLLILGKILGEEFGSVMEGNLKQEDGTSLKVAVKTMNSSQ
REIEEFLSEAACMKDFSHPNVIRLLGVCIEKPMVILPFMKYGDLHTYLLY
SRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDM
TVCVADFGLSMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPY
PGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLR
LQLEKLLESL
3D structure
PDB3brb Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 A725 R727 N728 D741 M762
Catalytic site (residue number reindexed from 1) D138 A140 R142 N143 D156 M161
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N728 D741 N143 D156
BS02 ADP A L593 V601 A617 K619 F673 M674 M730 L19 V26 A42 K44 F88 M89 M145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3brb, PDBe:3brb, PDBj:3brb
PDBsum3brb
PubMed19028587
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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