Structure of PDB 3bl9 Chain A

Receptor sequence
>3bl9A (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
LPFSGFRLQKVLRESARDKIIFLHGKVNEEDAVVILEKTPFQVEQVAQLL
TGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDL
RLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSD
GFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQG
QEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLL
AEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEA
3D structure
PDB3bl9 DcpS as a therapeutic target for spinal muscular atrophy.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DD2 A R54 F63 K142 Y143 W175 E185 D205 L206 R13 F22 K94 Y95 W127 E137 D157 L158 MOAD: ic50=43.94nM
PDBbind-CN: -logKd/Ki=7.18,IC50=66nM
BindingDB: IC50=43.94nM,EC50=67nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3bl9, PDBe:3bl9, PDBj:3bl9
PDBsum3bl9
PubMed18839960
UniProtQ96C86|DCPS_HUMAN m7GpppX diphosphatase (Gene Name=DCPS)

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