Structure of PDB 3bl7 Chain A

Receptor sequence
>3bl7A (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
LPFSGFRLQKVLRESARDKIIFLHGKVNEEDAVVILEKTPFQVEQVAQLL
TGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDL
RLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSD
GFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQG
QEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLL
AEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEA
3D structure
PDB3bl7 DcpS as a therapeutic target for spinal muscular atrophy.
ChainA
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DD1 A K142 Y143 W175 E185 D205 L206 S272 K94 Y95 W127 E137 D157 L158 S224 MOAD: ic50=7.62nM
PDBbind-CN: -logKd/Ki=8.40,IC50=4nM
BindingDB: IC50=0.030000nM,EC50=4.0nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3bl7, PDBe:3bl7, PDBj:3bl7
PDBsum3bl7
PubMed18839960
UniProtQ96C86|DCPS_HUMAN m7GpppX diphosphatase (Gene Name=DCPS)

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