Structure of PDB 3bkb Chain A

Receptor sequence
>3bkbA (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
PEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWD
GLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRA
VPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPP
DLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFL
RTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLK
ISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGI
LLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWA
YEPGQRPSFSTIYQELQSIRKRH
3D structure
PDB3bkb Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
ChainA
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D683 A685 R687 N688 D701 G718
Catalytic site (residue number reindexed from 1) D235 A237 R239 N240 D253 G270
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A I567 G568 R569 V575 A588 E607 E637 L638 V639 G642 R687 L690 S700 D701 I119 G120 R121 V127 A140 E159 E189 L190 V191 G194 R239 L242 S252 D253
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3bkb, PDBe:3bkb, PDBj:3bkb
PDBsum3bkb
PubMed18775312
UniProtP07332|FES_HUMAN Tyrosine-protein kinase Fes/Fps (Gene Name=FES)

[Back to BioLiP]