Structure of PDB 3biz Chain A

Receptor sequence
>3bizA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
SRYTTEFHELEKIGSSVFKCVKRLDGCIYAIKRSKKPSVDEQNALREVYA
HAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFK
EAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISKVMFKIGDLGHVTR
ISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRN
GDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL
3D structure
PDB3biz Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D426 K428
Catalytic site (residue number reindexed from 1) D127 K129
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 61E A I305 V313 A326 K328 V360 N376 E377 Y378 C379 G382 F433 D463 I13 V17 A30 K32 V61 N77 E78 Y79 C80 G83 F134 D144 MOAD: ic50=58nM
PDBbind-CN: -logKd/Ki=7.24,IC50=58nM
BindingDB: IC50=58nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3biz, PDBe:3biz, PDBj:3biz
PDBsum3biz
PubMed18191399
UniProtP30291|WEE1_HUMAN Wee1-like protein kinase (Gene Name=WEE1)

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