Structure of PDB 3bhi Chain A

Receptor sequence
>3bhiA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
SGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQA
EGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTP
FHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSP
ELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVT
VLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPV
YLALLPPDAEGPHGQFVSEKRVEQW
3D structure
PDB3bhi Human carbonyl reductase 1 is an s-nitrosoglutathione reductase
ChainA
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.184: carbonyl reductase (NADPH).
1.1.1.189: prostaglandin-E2 9-reductase.
1.1.1.196: 15-hydroxyprostaglandin-D dehydrogenase (NADP(+)).
1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP(+)).
1.1.1.71: alcohol dehydrogenase [NAD(P)(+)].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G11 N13 K14 G15 I16 R37 R41 D62 N89 A90 G91 V137 S139 Y193 K197 P227 W229 V230 T232 M234 G10 N12 K13 G14 I15 R36 R40 D61 N88 A89 G90 V136 S138 Y192 K196 P226 W228 V229 T231 M233
Gene Ontology
Molecular Function
GO:0004090 carbonyl reductase (NADPH) activity
GO:0005515 protein binding
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0050221 prostaglandin E2 9-reductase activity
GO:0160163 S-nitrosoglutathione reductase (NADPH) activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008211 glucocorticoid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0030855 epithelial cell differentiation
GO:0042373 vitamin K metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle

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Molecular Function
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Cellular Component
External links
PDB RCSB:3bhi, PDBe:3bhi, PDBj:3bhi
PDBsum3bhi
PubMed18826943
UniProtP16152|CBR1_HUMAN Carbonyl reductase [NADPH] 1 (Gene Name=CBR1)

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