Structure of PDB 3bgi Chain A

Receptor sequence
>3bgiA (length=231) Species: 10090 (Mus musculus) [Search protein sequence]
DAEVQKNQVLTLEDWKEKWVTRHISFHQEQGHQLLKKHLDTFLKGQSGLR
VFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLAE
IAGAKVFKSSSGSISLYCCSIFDLPRANIGKFDRIWDRGALVAINPGDHD
RYADIILSLLRKEFQYLVAVLSYDPTKHAGPPFYVPSAELKRLFGTKCSM
QCLEEVDALEERHKAWGLDYLFEKLYLLTEK
3D structure
PDB3bgi Structural Basis of Substrate Recognition in Thiopurine S-Methyltransferase
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.67: thiopurine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A L21 W24 W28 L64 C65 E85 I86 S129 I130 R147 L12 W15 W19 L55 C56 E76 I77 S120 I121 R138
Gene Ontology
Molecular Function
GO:0008119 thiopurine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3bgi, PDBe:3bgi, PDBj:3bgi
PDBsum3bgi
PubMed18484748
UniProtO55060|TPMT_MOUSE Thiopurine S-methyltransferase (Gene Name=Tpmt)

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