Structure of PDB 3bex Chain A

Receptor sequence
>3bexA (length=248) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
MDPMYLLVDVGNTHSVFSITEDGKTFRRWRLSTGVFQTEDELFSHLHPLL
GDAMREIKGIGVASVVPTQNTVIERFSQKYFHISPIWVKAKNGCVKWNVK
NPSEVGADRVANVVAFVKEYGKNGIIIDMGTATTVDLVVNGSYEGGAILP
GFFMMVHSLFRGTAKLPLVEVKPADFVVGKDTEENIRLGVVNGSVYALEG
IIGRIKEVYGDLPVVLTGGQSKIVKDMIKHEIFDEDLTIKGVYHFCFG
3D structure
PDB3bex Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase.
ChainA
Resolution1.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAU A E101 V102 G103 D105 R106 E104 V105 G106 D108 R109 MOAD: Kd=2.7uM
PDBbind-CN: -logKd/Ki=5.57,Kd=2.7uM
BS02 PAU A K162 T179 K165 T182 MOAD: Kd=2.7uM
PDBbind-CN: -logKd/Ki=5.57,Kd=2.7uM
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0043169 cation binding
GO:0046872 metal ion binding
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3bex, PDBe:3bex, PDBj:3bex
PDBsum3bex
PubMed18186650
UniProtQ9WZY5|COAX_THEMA Type III pantothenate kinase (Gene Name=coaX)

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