Structure of PDB 3bej Chain A

Receptor sequence
>3bejA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNH
VQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKGHSDL
LEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQY
IKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHH
AEMLMSWRVNDHKFTPLLCEIWDV
3D structure
PDB3bej Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V299 K303 H313 E314 I317 L320 K321 L464 E467 V55 K59 H69 E70 I73 L76 K77 L217 E220
BS02 MUF A M265 F284 L287 T288 M290 R331 S332 W454 F461 M21 F40 L43 T44 M46 R87 S88 W207 F214
Gene Ontology
Molecular Function
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3bej, PDBe:3bej, PDBj:3bej
PDBsum3bej
PubMed18391212
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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