Structure of PDB 3bcn Chain A

Receptor sequence
>3bcnA (length=209) Species: 52861 (Tabernaemontana divaricata) [Search protein sequence]
LPEHVDWRAKGAVIPLKNQGKCGSCWAFSTVTTVESINQIRTGNLISLSE
QQLVDCSKKNHGCKGGYFDRAYQYIIANGGIDTEANYPYKAFQGPCRAAK
KVVRIDGCKGVPQCNENALKNAVASQPSVVAIDASSKQFQHYKGGIFTGP
CGTKLNHGVVIVGYGKDYWIVRNSWGRHWGEQGYTRMKRVGGCGLCGIAR
LPFYPTKAA
3D structure
PDB3bcn Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H157 N173
Catalytic site (residue number reindexed from 1) Q19 C25 H157 N173
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E64 A G23 C25 W26 G65 G66 N156 H157 G23 C25 W26 G65 G66 N156 H157 PDBbind-CN: -logKd/Ki=7.12,IC50=76.25nM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome

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Cellular Component
External links
PDB RCSB:3bcn, PDBe:3bcn, PDBj:3bcn
PDBsum3bcn
PubMed18167146
UniProtA5YVK8|ERVA_TABDI Ervatamin-A (Fragment)

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