Structure of PDB 3bab Chain A

Receptor sequence
>3babA (length=312) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
LTLTAATTRAQELRKQLNQYSHEYYVKDQPSVEDYVYDRLYKELVDIETE
FPDLITPDSPTQRVGGKVLSGFEKAPHDIPMYSLNDGFSKEDIFAFDERV
RKAIGKPVAYCCELKIDGLAISLRYENGVFVRGATRGDGTVGENITENLR
TVRSVPMRLTEPISVEVRGECYMPKQSFVALNEEREENGQDIFANPRNAA
AGSLRQLDTKIVAKRNLNTFLYTVADFGPMKAKTQFEALEELSAIGFRTN
PERQLCQSIDEVWAYIEEYHEKRSTLPYEIDGIVIKVNEFALQDELGFTV
KAPRWAIAYKFP
3D structure
PDB3bab Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E118 K120 D122 Y227 K315
Catalytic site (residue number reindexed from 1) E113 K115 D117 Y222 K310
Enzyme Commision number 6.5.1.2: DNA ligase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NMN A Y25 Y29 Y30 D39 Y42 D43 R158 Y20 Y24 Y25 D34 Y37 D38 R153
BS02 3BD A L89 K120 I121 A125 E175 Y227 K291 W310 L84 K115 I116 A120 E170 Y222 K286 W305
Gene Ontology
Molecular Function
GO:0003911 DNA ligase (NAD+) activity

View graph for
Molecular Function
External links
PDB RCSB:3bab, PDBe:3bab, PDBj:3bab
PDBsum3bab
PubMed
UniProtQ837V6|DNLJ_ENTFA DNA ligase (Gene Name=ligA)

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