Structure of PDB 3b98 Chain A

Receptor sequence
>3b98A (length=446) Species: 7955 (Danio rerio) [Search protein sequence]
RTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGL
YITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKR
AEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLL
FKTGYLTVFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIAS
AAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQL
WVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQNTPVFDSVLWETLRLTA
AALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEM
FQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKE
LVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR
3D structure
PDB3b98 Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
ChainA
Resolution2.08 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.2.1.152: hydroperoxy icosatetraenoate dehydratase.
5.3.99.4: prostaglandin-I synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A K119 V273 T274 N277 W414 C421 P422 G423 F426 A427 K98 V252 T253 N256 W381 C388 P389 G390 F393 A394
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008116 prostaglandin-I synthase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3b98, PDBe:3b98, PDBj:3b98
PDBsum3b98
PubMed18032380
UniProtF1RE08|PTGIS_DANRE Prostacyclin synthase (Gene Name=ptgis)

[Back to BioLiP]