Structure of PDB 3b6p Chain A

Receptor sequence
>3b6pA (length=217) Species: 10090 (Mus musculus) [Search protein sequence]
GHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPPPVP
RPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILL
RAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAA
LKALEQAKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALLQ
WVDEHARPFSTVKPMYG
3D structure
PDB3b6p Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D18 E20 D200 D10 E12 D183
BS02 NA A D18 D130 D10 D122
BS03 TMP A E20 A21 I84 Y129 H195 E12 A13 I76 Y121 H178
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3b6p, PDBe:3b6p, PDBj:3b6p
PDBsum3b6p
PubMed18780819
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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