Structure of PDB 3b68 Chain A

Receptor sequence
>3b68A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
3D structure
PDB3b68 Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B68 A L704 N705 L707 G708 Q711 W741 M742 M745 V746 M749 F764 T877 M895 I899 V903 L34 N35 L37 G38 Q41 W71 M72 M75 V76 M79 F94 T207 M225 I229 V233 PDBbind-CN: -logKd/Ki=8.40,Ki=4nM
BindingDB: Ki=4nM
External links
PDB RCSB:3b68, PDBe:3b68, PDBj:3b68
PDBsum3b68
PubMed18805694
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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