Structure of PDB 3b5r Chain A

Receptor sequence
>3b5rA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
3D structure
PDB3b5r Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B5R A L704 N705 L707 G708 W741 M742 M745 V746 M749 F764 T877 M895 V903 L34 N35 L37 G38 W71 M72 M75 V76 M79 F94 T207 M225 V233 PDBbind-CN: -logKd/Ki=8.77,Ki=1.7nM
BindingDB: Ki=1.7nM
External links
PDB RCSB:3b5r, PDBe:3b5r, PDBj:3b5r
PDBsum3b5r
PubMed18805694
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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