Structure of PDB 3b2w Chain A

Receptor sequence
>3b2wA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
WEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLA
EANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLT
INKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLAR
LIEDNEYTAGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRI
PYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDY
LRSVLEDFFTA
3D structure
PDB3b2w N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D364 R366 A368 N369 D382 A400 F402
Catalytic site (residue number reindexed from 1) D127 R129 A131 N132 D145 A161 F163
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9NH A V259 A271 K273 E288 M292 L300 T316 Y318 M319 G322 L371 A381 D382 F383 V22 A34 K36 E51 M55 L63 T79 Y81 M82 G85 L134 A144 D145 F146 MOAD: ic50=0.6nM
PDBbind-CN: -logKd/Ki=9.22,IC50=0.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3b2w, PDBe:3b2w, PDBj:3b2w
PDBsum3b2w
PubMed18083554
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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