Structure of PDB 3b2r Chain A

Receptor sequence
>3b2rA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFT
DLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALK
AGKIQNKLTDLEILALLIAALSHDLDHRGVCHSIMEHHHFDQCLMILNSP
GNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNL
EDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDKKNKI
PSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ
3D structure
PDB3b2r Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
ChainA
Resolution2.07 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VDN A Y612 H613 C677 I680 M816 Q817 F820 Y82 H83 C131 I134 M253 Q254 F257 BindingDB: IC50=0.890000nM,Ki=1nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3b2r, PDBe:3b2r, PDBj:3b2r
PDBsum3b2r
PubMed17959709
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

[Back to BioLiP]