Structure of PDB 3aw8 Chain A

Receptor sequence
>3aw8A (length=360) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MIGILGGGQLGRMLALAGYPLGLSFRFLDPSPEACAGQVGELVVGEFLDE
GALLRFAEGLALVTYEFENVPVEAARRLEGRLPLYPPAKALEVAQDRLRE
KTFFQGLGVPTPPFHPVDGPEDLEEGLKRVGLPALLKTRRGQALVRTEEE
ALEALKALGGRGLILEGFVPFDREVSLLAVRGRTGEVAFYPLVENRHWGG
ILRLSLAPAPGASEALQKKAEAYALRAMEALDYVGVLALEFFQVGEELLF
NEMAPRVHNSGHWTIEGAETSQFENHLRAVLGLPLGSTAPRGQSAMVNLI
GEKPPFAEVLKVEGAHLHWYGKAVRPGRKVGHITLRRDGLKALEEGLARL
SRLVSELPWE
3D structure
PDB3aw8 Crystal structures of N5-carboxyaminoimidazole ribonucleotide synthetase, PurK, from thermophilic bacteria
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E246 E258 N265 S266 K335
Catalytic site (residue number reindexed from 1) E240 E252 N259 S260 K329
Enzyme Commision number 6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A L135 K137 Q148 F174 V175 E180 H203 F248 E258 L135 K137 Q142 F168 V169 E174 H197 F242 E252
Gene Ontology
Molecular Function
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0034028 5-(carboxyamino)imidazole ribonucleotide synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3aw8, PDBe:3aw8, PDBj:3aw8
PDBsum3aw8
PubMed
UniProtQ5SKY0

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