Structure of PDB 3av7 Chain A

Receptor sequence

>3av7A (length=404) Species: 70601 (Pyrococcus horikoshii OT3)

SMLGDVERFFSKKALEMRASEVRELLKLVETSDIISLAGGLPNPKTFPKE
IIRDILVEIMEKYADKALQYGTTKGFTPLRETLMKWLGKRYGISQDNDIM
ITSGSQQALDLIGRVFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIPLD
DEGMKVEILEEKLKELKSQGKKVKVVYTVPTFQNPAGVTMNEDRRKYLLE
LASEYDFIVVEDDPYGELRYSGNPEKKIKALDNEGRVIYLGTFSKILAPG
FRIGWMVGDPGIIRKMEIAKQSTDLCTNVFGQVVAWRYVDGGYLEKHIPE
IRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWVTLPDGIDSKKMLE
RAIKKGVAYVPGEAFYAHRDVKNTMRLNFTYVDEDKIMEGIKRLAETIKE
ELKA

3D structure

• PDB: 3av7 Structural insight into kynurenic acid excretion mechanisms of kynurenine aminotransferase in the hyperthermophilic archaeon Pyrococcus horikoshii
• Chain: A
• Resolution: 1.84 Å

Enzymatic activity

• Enzyme Commision number: 2.6.1.7: kynurenine--oxoglutarate transaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PMP	A	G128 S129 Q130 Y154 V203 N208 D236 P238 Y239 T266 S268 K269 R276	G104 S105 Q106 Y130 V179 N184 D212 P214 Y215 T242 S244 K245 R252
BS02	KYN	A	R47 G64 Y154 L155 A156 N208 R400	R23 G40 Y130 L131 A132 N184 R376
BS03	KYA	A	S44 V46 R47 L155 Q159 A388 R393	S20 V22 R23 L131 Q135 A364 R369

Gene Ontology

Molecular Function

• GO:0008483 transaminase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0009058 biosynthetic process
• GO:1901605 alpha-amino acid metabolic process

External links

• PDB: RCSB:3av7, PDBe:3av7, PDBj:3av7
• PDBsum: 3av7
• UniProt: O57946