Structure of PDB 3av5 Chain A

Receptor sequence
>3av5A (length=1139) Species: 10090 (Mus musculus) [Search protein sequence]
PKCPECGQHLDDPNLKYQQHPEDAVDEPQMLTSEKLSTYEDSPMHRFTSF
SVYCSRGHLCPVDTGLIEKNVELYFSGCAKAIHDENPSMEGGINGKNLGP
INQWWLSGFDGGEKVLIGFSTAFAEYILMEPSKEYEPIFGLMQEKIYISK
IVVEFLQNNPDAVYEDLINKIETTVPPSTINVNRFTEDSLLRHAQFVVSQ
VESYDEAKDDDETPIFLSPCMRALIHLAGVSLGQRRATRPTKATTTKLVY
QIFDTFFSEQIEKRRRCGVCEVCQQPECGACLKRRCPNLAVKEADDDEEA
DDEMPSPKKLHQGKKKKQNKDRISWLGQPMKIERTYYQKVSIDEEMLEVG
DCVSVIPDDSSKPLYLARVTALWEDKNGQMMFHAHWFCAGTDTVLGATSD
PLELFLVGECENMQLSYIHSKVKVIYKAPSENWAMEGGKTYFFQLWYNQE
YARFESPPKTQPTEDNKHKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVY
CSSITKNGVVYRLGDSVYLPPEAFTFNIKVKKDPVNETLYPEHYRKYSLD
APEPYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHT
DINMLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLE
AYNSKTKNFEDPPNHARSKLPKLRTLDVFSGCGGLSEGFHQAGISETLWA
IEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKGD
VEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLE
NVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIIL
AAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTIT
VRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKD
MSPLVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGY
SSTGALRGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRL
EWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFG
NILDRHRQVGNAVPPPLAKAIGLEIKLCLLSSARESASA
3D structure
PDB3av5 Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1).
ChainA
Resolution3.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C760 E800 R844 R846
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006346 DNA methylation-dependent heterochromatin formation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3av5, PDBe:3av5, PDBj:3av5
PDBsum3av5
PubMed21518897
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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