Structure of PDB 3au6 Chain A

Receptor sequence
>3au6A (length=562) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MRNQELARIFEEIGLMSEFLGDNPFRVRAYHQAARTLYDLDTPIEEIAEK
GKEALMELPGVGPDLAEKILEFLRTGKVRKHEELSRKVPRGVLEVMEVPG
VGPKTARLLYEGLGIDSLEKLKAALDRGFGPKRAERIREGLALAQAAGKR
RPLGAVLSLARSLLEAIRALPGVERAELCGSARRYKDTVGDLDFLVASRE
GERAVEGFVRLPQVKEVYAKGKERATVFLKNGLQVDLRVVPPESYGAGLQ
YLTGSKAHSIRLRALAQEKGLKLSEYGVFRGEKRIAGETEEEVYAALGLP
WIPPPLREDQGEVEAALEGRLPKLLELPQVKGDLQVHSTYSDGQNTLEEL
WEAAKTMGYRYLAVTDHSPAVRVGPSPEEALKRVGEIRRFNETHGPPYLL
AGAEVDIHPDGTLDYPDWVLRELDLVLVSVHSRFNLPKADQTKRLLKALE
NPFVHVLAHPTARLLGRRAPIEADWEAVFQKAKEKGVAVEIDGYYDRMDL
PDDLARMAYGMGLWISLSTDAHQTDHLRFMELAVGTAQRAWIGPERVLNT
LDYEDLLSWLKA
3D structure
PDB3au6 The structural basis of the kinetic mechanism of a gap-filling X-family DNA polymerase that binds Mg(2+)-dNTP before binding to DNA.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R231 I267 R270 Q274 K279 E282 Y283 R224 I260 R263 Q267 K272 E275 Y276
BS02 DG3 A R157 G187 S188 R191 V196 G197 D198 D200 Y258 K263 R270 R150 G180 S181 R184 V189 G190 D191 D193 Y251 K256 R263 PDBbind-CN: -logKd/Ki=7.92,Kd=12nM
BS03 MG A S188 D198 D200 S181 D191 D193
BS04 MG A D198 D200 D191 D193
BS05 ZN A E413 H468 E404 H459
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
GO:0042578 phosphoric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0071897 DNA biosynthetic process
GO:0071978 bacterial-type flagellum-dependent swarming motility
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3au6, PDBe:3au6, PDBj:3au6
PDBsum3au6
PubMed22306405
UniProtQ5SJ64

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