Structure of PDB 3at3 Chain A

Receptor sequence
>3at3A (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKY
SEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADI
VKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSM
GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP
ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG
TEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA
3D structure
PDB3at3 A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 K158 N161 D175 P184 S194
Catalytic site (residue number reindexed from 1) D156 K158 N161 D175 P184 S194
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATK A L45 V53 V66 K68 F113 V116 M163 I174 D175 L45 V53 V66 K68 F113 V116 M163 I174 D175 PDBbind-CN: -logKd/Ki=8.04,IC50=9.2nM
BindingDB: IC50=110nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3at3, PDBe:3at3, PDBj:3at3
PDBsum3at3
PubMed21735094
UniProtP68400|CSK21_HUMAN Casein kinase II subunit alpha (Gene Name=CSNK2A1)

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