Structure of PDB 3ask Chain A

Receptor sequence
>3askA (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
SLYKVNEYVDARDTNMGAWFEAQVVRVTRKAEEDVIYHVKYDDYPENGVV
QMNSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKR
ETRTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRK
SGPSCKHCKDDVNRLCRVCACHLCGGRQDKQLMCDECDMAFHIYCPPLSS
VPSEDEWYCPECR
3D structure
PDB3ask Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
ChainA
Resolution2.904 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F152 Y188 D190 Y191 E193 Q330 L331 M332 D334 D337 E355 D356 F20 Y41 D43 Y44 E46 Q181 L182 M183 D185 D188 E204 D205
BS02 ZN A C302 C305 C313 C316 C155 C158 C166 C169
BS03 ZN A C318 H341 C171 H192
BS04 ZN A C333 C336 C360 C363 C184 C187 C209 C212
External links
PDB RCSB:3ask, PDBe:3ask, PDBj:3ask
PDBsum3ask
PubMed22837395
UniProtQ96T88|UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (Gene Name=UHRF1)

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