Structure of PDB 3aqa Chain A

Receptor sequence
>3aqaA (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
GRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMD
MGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKI
FLQKVASMPQEEQE
3D structure
PDB3aqa Real-Time Imaging of Histone H4K12-Specific Acetylation Determines the Modes of Action of Histone Deacetylase and Bromodomain Inhibitors
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BYH A W97 P98 L108 N156 M165 W25 P26 L36 N84 M93 PDBbind-CN: -logKd/Ki=4.55,Kd=28uM
BindingDB: Kd=28000nM,IC50=28000nM
External links
PDB RCSB:3aqa, PDBe:3aqa, PDBj:3aqa
PDBsum3aqa
PubMed21513886
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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