Structure of PDB 3ao4 Chain A

Receptor sequence
>3ao4A (length=139) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTGATVRAACDWAGIKQEIESMNKELKKIIGQVRDQ
AEHLKTAVQMAVFIHNHKRKGGIGGYSAGERIVDIIATD
3D structure
PDB3ao4 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 833 A H185 G197 E198 H117 G129 E130 MOAD: Kd=8.5mM
PDBbind-CN: -logKd/Ki=2.07,Kd=8.5mM
BS02 833 A G106 R107 W108 P109 I204 D207 G50 R51 W52 P53 I136 D139 MOAD: Kd=8.5mM
PDBbind-CN: -logKd/Ki=2.07,Kd=8.5mM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3ao4, PDBe:3ao4, PDBj:3ao4
PDBsum3ao4
PubMed21275048
UniProtQ72498

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