Structure of PDB 3akk Chain A

Receptor sequence
>3akkA (length=296) Species: 85963 (Helicobacter pylori J99) [Search protein sequence]
PTIDFTFCEINPKKGFGGANGNKISLFYNNELYMVKFPPKPSTHKEMSYT
NGCFSEYVACHIVNSLGLKVQETLLGTYKNKIVVACKDFTTHQYELVDFL
SLKNTMIELEKSGKDTNLNDVLYAIDNQHFIEPKVLKCFFWDMFVADTLL
GNFDRHNGNWGFLRASNSKEYQIAPIFDCGSCLYPQADDVVCQKVLSNID
ELNARIYNFPQSILKDDNDKKINYYDFLTQTNNKDCLDALLRIYPRIDMN
KIHSIIDNTPFMSEIHKEFLHTMLDERKSKIIDVAHTRAIELSLQH
3D structure
PDB3akk Helicobacter pylori proinflammatory protein up-regulates NF-kappaB as a cell-translocating Ser/Thr kinase
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N160 D179 N159 D178
BS02 ADP A G18 N21 K24 M35 K37 D89 F90 L97 D179 G17 N20 K23 M34 K36 D88 F89 L96 D178
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0006338 chromatin remodeling
GO:0016310 phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus
GO:0044164 host cell cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3akk, PDBe:3akk, PDBj:3akk
PDBsum3akk
PubMed21098302
UniProtQ9ZKJ5|CTKA_HELPJ Serine/threonine-protein kinase CtkA (Gene Name=ctkA)

[Back to BioLiP]