Structure of PDB 3agp Chain A

Receptor sequence
>3agpA (length=1202) Species: 39803,83334 [Search protein sequence]
AEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAK
KAGNVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAV
AGKITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGAR
IGVLVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDI
AMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNA
EVTGFIRFEVGEGIEKVETDFAAEVAAMSKQSHMSFERTKPHVNVGTIGH
VDHGKTTLTAAITTVLAKTYGGTSHVEYDTPTRHYAHVDCPGHADYVKNM
ITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVD
DEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILEL
AGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGEE
VEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQV
LAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTI
ELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAKV
LSGASSRNSLSAQLRRAANTRIEVEGNLALSIANDLLLAYGQSPFNSEAE
CISFSPRFDGTPDDFRINYLKAEIMSKYDDFSLGIDTEAVAWEKFLAAEA
ECALTNARLYRPDYSEDFNFSLGESCIHMARRKIAKLIGDVPSVEGMLRH
CRFSGGATTTNNRSYGHPSFKFALPQACTPRALKYVLALRASTHFDIRIS
DISPFNKAVTVPKNSKTDRCIAIEPGWNMFFQLGIGGILRDRLRCWGIDL
NDQTINQRRAHEGSVTNNLATVDLSAASDSISLALCELLLPPGWFEVLMD
LRSPKGRLPDGSVVTYEKISSMGNGYTFELESLIFASLARSVCEILDLDS
SEVTVYGDDIILPSCAVPALREVFKYVGFTTNTKKTFSEGPFRESCGKHY
YSGVDVTPFYIRHRIVSPADLILVLNNLYRWATIDGVWDPRAHSVYLKYR
KLLPKQLQRNTIPDGYGDGALVGSVLINPFAKNRGWIRYVPVITDHTRDR
ERAELGSYLYDLFSRCLSESNAIDQLICRSNPTKISRSTGKFDIQYIACS
SR
3D structure
PDB3agp Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D306 K309 T310 H369
Catalytic site (residue number reindexed from 1) D302 K305 T306 H343
Enzyme Commision number ?
2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D968 D1054 E1089 D923 D1009 E1044
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006412 translation
GO:0006414 translational elongation
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3agp, PDBe:3agp, PDBj:3agp
PDBsum3agp
PubMed20798060
UniProtP0A6N3;
P0A6P3;
P14647|RDRP_BPQBE RNA-directed RNA polymerase subunit beta

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