Structure of PDB 3ag6 Chain A

Receptor sequence
>3ag6A (length=283) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence]
MTKLITTVKEMQHIVKAAKRSGTTIGFIPTMGALHDGHLTMVRESVSTND
ITIVSVFVNPLQFGPNEDFDAYPRQIDKDLELVSEVGADIVFHPAVEDMY
PGELGIDVKVGPLADVLEGAKRPGHFDGVVTVVNKLFNIVMPDYAYFGKK
DAQQLAIVEQMVKDFNHAVEIIGIDIVREADGLAKSSRNVYLTEQERQEA
VHLSKSLLLAQALYQDGERQSKVIIDRVTEYLESHISERIEEVAVYSYPQ
LVEQHEITGRIFISLAVKFSKARLIDNIIIGAE
3D structure
PDB3ag6 Substrate-induced closing of the active site revealed by the crystal structure of pantothenate synthetase from Staphylococcus aureus.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M31 H35 H38 K78 D79 L82 K150 S186 S187 R188
Catalytic site (residue number reindexed from 1) M31 H35 H38 K78 D79 L82 K150 S186 S187 R188
Enzyme Commision number 6.3.2.1: pantoate--beta-alanine ligase (AMP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAJ A P29 T30 M31 H35 H38 M41 Q62 V132 F147 G148 D151 Q154 I176 V177 K185 P29 T30 M31 H35 H38 M41 Q62 V132 F147 G148 D151 Q154 I176 V177 K185
Gene Ontology
Molecular Function
GO:0004592 pantoate-beta-alanine ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0015940 pantothenate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ag6, PDBe:3ag6, PDBj:3ag6
PDBsum3ag6
PubMed20568730
UniProtQ2FV22|PANC_STAA8 Pantothenate synthetase (Gene Name=panC)

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