Structure of PDB 3aeo Chain A

Receptor sequence
>3aeoA (length=387) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
AQDITTTLLHPKGDHVLHSHAYPIFQTSTFCFDSTQQGADLFMGKGEGHI
YSRLGNPTVEQFEEMVCSIEGAAGSAAFGSGMGAISSSTLAFLQKGDHLI
AGDTLYGCTVSLFTHWLPRFGIEVDLIDTSDVEKVKAAWKPNTKMVYLES
PANPTCKVSDIKGIAVVCHERGARLVVDATFTSPCFLKPLELGADIALHS
VSKYINGHGDVIGGVSSAKTAEDIATIKFYRKDAGSLMAPMDAFLCARGM
KTLPIRMQIHMENGLKVAKFLEQHEKIVKVNHPGLESFPGHDIAKKQMTG
YGSTFLFEMKSFEAAKKLMEHLKVCTLAVSLGCVDTLIEHPASMTHAAVP
ENIMRKQGITPELVRISVGIENVDDIIADLKQALELW
3D structure
PDB3aeo Crystal structure of Entamoeba histolytica methionine gamma-lyase 1
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.1.11: methionine gamma-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3LM A G83 M84 Y108 E151 N155 D180 S202 S204 K205 V331 S332 T347 R367 G81 M82 Y106 E149 N153 D178 S200 S202 K203 V329 S330 T345 R365
BS02 3LM A Y53 R55 Y51 R53
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:0018826 methionine gamma-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:3aeo, PDBe:3aeo, PDBj:3aeo
PDBsum3aeo
PubMed
UniProtQ86D28

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