Structure of PDB 3ae4 Chain A

Receptor sequence

>3ae4A (length=613) Species: 9823 (Sus scrofa) [Search protein sequence]

STQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTV
AAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVV
ELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLL
HTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRARN
TVVATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIY
GAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEI
REGRGCGPEKDHVYLQLHHLPPEQLAVRLPGISETAMIFAGVDVTKEPIP
VLPTVHYNMGGIPTNYKGQVLRHVNGQDQVVPGLYACGEAACASVHGANR
LGANSLLDLVVFGRACALSIAESCRPGDKVPSIKPNAGEESVMNLDKLRF
ANGTIRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKILRLYGDLQHLKT
FDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDFKERV
DEYDYSKPIQGQQKKPFQEHWRKHTLSYVDVKTGKVSLEYRPVIDKTLNE
ADCATVPPAIRSY

3D structure

PDB

3ae4 Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-methyl-benzamide

Chain

Resolution

2.91 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	F131 Q252 H254 L264 E267 R270 R298 H365 Y366 R409
Catalytic site (residue number reindexed from 1)	F122 Q243 H245 L255 E258 R261 R289 H356 Y357 R400
Enzyme Commision number	1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G26 A27 G28 A30 T49 K50 S56 H57 T58 A60 A61 Q62 G64 Y177 F178 A179 T214 G215 D233 L264 H365 Y366 E398 R409 A412 S414 L415 L418	G17 A18 G19 A21 T40 K41 S47 H48 T49 A51 A52 Q53 G55 Y168 F169 A170 T205 G206 D224 L255 H356 Y357 E389 R400 A403 S405 L406 L409

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0008177	succinate dehydrogenase (quinone) activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006099	tricarboxylic acid cycle
GO:0006121	mitochondrial electron transport, succinate to ubiquinone
GO:0022900	electron transport chain

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0045273	respiratory chain complex II (succinate dehydrogenase)

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3ae4, PDBe:3ae4, PDBj:3ae4
PDBsum	3ae4
PubMed
UniProt	Q0QF01\|SDHA_PIG Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Gene Name=SDHA)

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