Structure of PDB 3adu Chain A

Receptor sequence
>3aduA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDM
NSLMMGEDEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP
LLQEIYKDL
3D structure
PDB3adu The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
ChainA
Resolution2.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYI A C285 R288 L330 L333 C68 R71 L113 L116 PDBbind-CN: -logKd/Ki=4.14,Kd=72.8uM
BS02 MYI A F282 C285 S289 H323 Y327 F363 H449 Y473 F65 C68 S72 H106 Y110 F146 H232 Y256 PDBbind-CN: -logKd/Ki=4.14,Kd=72.8uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:3adu, PDBe:3adu, PDBj:3adu
PDBsum3adu
PubMed20717101
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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