Structure of PDB 3ads Chain A

Receptor sequence
>3adsA (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDM
NSLMMGEDKIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQ
VTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFM
EPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLL
QALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMS
LHPLLQEIYKDL
3D structure
PDB3ads The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMN A R280 G284 C285 R288 I341 S342 M348 R66 G70 C71 R74 I127 S128 M134 MOAD: Kd=9.73uM
PDBbind-CN: -logKd/Ki=5.01,Kd=9.73uM
BindingDB: EC50=50000nM
BS02 IMN A I281 F282 C285 S289 H323 F360 F363 M364 H449 L469 Y473 I67 F68 C71 S75 H109 F146 F149 M150 H235 L255 Y259 MOAD: Kd=9.73uM
PDBbind-CN: -logKd/Ki=5.01,Kd=9.73uM
BindingDB: EC50=50000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ads, PDBe:3ads, PDBj:3ads
PDBsum3ads
PubMed20717101
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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