Structure of PDB 3ade Chain A

Receptor sequence
>3adeA (length=289) Species: 10090 (Mus musculus) [Search protein sequence]
GRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLL
YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGH
IYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYA
VGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGG
YDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDG
HTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
3D structure
PDB3ade The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y334 S363 R380 N382 R415 S508 Y525 Q530 S555 A556 Y572 F577 S602 Y10 S39 R56 N58 R91 S184 Y201 Q206 S231 A232 Y248 F253 S278
External links
PDB RCSB:3ade, PDBe:3ade, PDBj:3ade
PDBsum3ade
PubMed20173742
UniProtQ9Z2X8|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)

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