Structure of PDB 3adc Chain A

Receptor sequence

>3adcA (length=246) Species: 243232 (Methanocaldococcus jannaschii DSM 2661)

HHMLIILTGLPGVGKSTFSKNLAKILSKNNIDVIVLGSDLIRESFPVWKE
KYEEFIKKSTYRLIDSALKNYWVIVDDTNYYNSMRRDLINIAKKYNKNYA
IIYLKASLDVLIRRNIERGEKIPNEVIKKMYEKFDEPGKKYKWDEPFLII
DTTKDIDFNEIAKKLIEKSKEIPKFYVLEENNNISDKIDKETRKIVSEYI
KSKKLDKDKIKEVVELRKEFLKKIKKMEEVDADRVLKEFKDLLNSY

3D structure

• PDB: 3adc Structural Basis for the Major Role of O-Phosphoseryl-tRNA Kinase in the UGA-Specific Encoding of Selenocysteine
• Chain: A
• Resolution: 2.9 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.164: O-phosphoseryl-tRNA(Sec) kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R40 W46 E48 E51 K55 Y78 Y79 N80 S81 M82 R84 I120 V124 M128 D133 K137 K138 Y139 K140 W141 K192 R195 S199 I202 K203 K209 I212 V216 R219 K220 K224 K227	R42 W48 E50 E53 K57 Y80 Y81 N82 S83 M84 R86 I122 V126 M130 D135 K139 K140 Y141 K142 W143 K190 R193 S197 I200 K201 K207 I210 V214 R217 K218 K222 K225
BS02	ANP	A	G10 G12 K13 S14 T15 R112 R116 T150	G12 G14 K15 S16 T17 R114 R118 T152
BS03	MG	A	S14 D74	S16 D76

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0016773 phosphotransferase activity, alcohol group as acceptor
• GO:0043915 L-seryl-tRNA(Sec) kinase activity

Biological Process

• GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec
• GO:0002098 tRNA wobble uridine modification
• GO:0016310 phosphorylation

External links

• PDB: RCSB:3adc, PDBe:3adc, PDBj:3adc
• PDBsum: 3adc
• PubMed: 20705242
• UniProt: Q58933|PSTK_METJA L-seryl-tRNA(Sec) kinase (Gene Name=pstK)