Structure of PDB 3acx Chain A

Receptor sequence
>3acxA (length=284) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDS
IDVYGDIQFLNQIKEDIQSIEKYPYEYHHFQSDRRIMMALQHVAQHKNIA
FQSFYNLIDTVYKDQHFTMFETDAELFGYCYGVAGTVGEVLTPILSDHET
HQTYDVARRLGESLQLINILRDVGEDFENERIYFSKQRLKQYEVDIAEVY
QNGVNNHYIDLWEYYAAIAEKDFRDVMDQIKVFSIEAQPIIELAARIYIE
ILDEVRQANYTLHERVFVEKRKKAKLFHEINSKY
3D structure
PDB3acx Mechanism of action and inhibition of dehydrosqualene synthase
ChainA
Resolution1.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.96: 4,4'-diapophytoene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 673 A H18 F22 F26 Y41 A134 V137 G138 L141 L145 A157 L160 G161 H18 F22 F26 Y41 A134 V137 G138 L141 L145 A157 L160 G161 PDBbind-CN: -logKd/Ki=5.70,Ki=2uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004311 farnesyltranstransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016767 geranylgeranyl-diphosphate geranylgeranyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0016117 carotenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3acx, PDBe:3acx, PDBj:3acx
PDBsum3acx
PubMed21098670
UniProtA9JQL9|CRTM_STAAU 4,4'-diapophytoene synthase (Gene Name=crtM)

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