Structure of PDB 3acc Chain A

Receptor sequence
>3accA (length=166) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
GMFTPGNGPVQISAEAIKKRVEELGGEIARDYQGKTPHLICVLNGAFIFM
ADLVRAIPLPLTMDFIAISSYLLKDLRLPIHGRDVIVVEDIVDTGLTLSY
LLDYLEARKPASVRVAALLSKPSRRQVEVPIHYLGFEIEDAYVYGYGLDR
AQFDRNLPFITSIRPE
3D structure
PDB3acc Structures of hypoxanthine-guanine phosphoribosyltransferase (TTHA0220) from Thermus thermophilus HB8.
ChainA
Resolution2.16 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E102 D103 D106 Y155 R168
Catalytic site (residue number reindexed from 1) E89 D90 D93 Y142 R155
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP A D103 I104 D106 T107 G108 T110 K134 Y155 V156 D90 I91 D93 T94 G95 T97 K121 Y142 V143
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3acc, PDBe:3acc, PDBj:3acc
PDBsum3acc
PubMed20693661
UniProtQ5SLS3

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